CRISPR/Cas9 mediated mutation of the mtnr1a melatonin receptor gene causes rod photoreceptor degeneration in developing Xenopus tropicalis
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چکیده
منابع مشابه
A null mutation in the photoreceptor guanylate cyclase gene causes the retinal degeneration chicken phenotype.
The retinas of the retinal degeneration (rd) chicken are fully developed and possess normal morphology at hatching but fail to respond to light stimulation. Analyses of retinal cGMP, the internal messenger of phototransduction, show that the amount of cGMP in predegenerate, fully developed rd/rd photoreceptors is 5-10 times less than that seen in normal photoreceptor cells. We show that the low...
متن کاملA mutation in the cone-specific pde6 gene causes rapid cone photoreceptor degeneration in zebrafish.
Photoreceptor degeneration is a common cause of inherited blindness worldwide. We have identified a blind zebrafish mutant with rapid degeneration of cone photoreceptors caused by a mutation in the cone phosphodiesterase c (pde6c) gene, a key regulatory component in cone phototransduction. Some rods also degenerate, primarily in areas with a low density of rods. Rod photoreceptors in areas of t...
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Crx is a novel paired-like homeodomain protein that is expressed predominantly in retinal photoreceptors and pinealocytes. Its gene has been mapped to chromosome 19q13.3, the site of a disease locus for autosomal dominant cone-rod dystrophy (CORDII). Analysis of the proband from a family with autosomal dominant CORD revealed an Arg41Trp substitution in the third residue of the CRX homeodomain. ...
متن کاملDirect modulation of rod photoreceptor responsiveness through a Mel(1c) melatonin receptor in transgenic Xenopus laevis retina.
PURPOSE Retinal circadian signals may have a role in maintaining the normal function and health of photoreceptors. Melatonin is an output of the retinal circadian oscillator and provides nocturnal signaling that is mediated through specific G-protein-coupled receptors. Melatonin receptors are expressed in retinal photoreceptor cells, and this study was undertaken to test the hypothesis that mel...
متن کاملMapping of the melatonin receptor 1a (MTNR1A) gene in pigs, sheep, and cattle.
and Implications Human and sheep Melatonin receptor 1a (MTNR1A) gene information was used to clone a portion of the coding region of this gene in pigs, and to identify polymorphisms of the gene for its assignment to both the genetic linkage and physical maps. MTNR1A maps to pig chromosome 17, establishing a new region of conserved synteny between this chromosome and human chromosome 4. Furtherm...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2020
ISSN: 2045-2322
DOI: 10.1038/s41598-020-70735-2